Multiplexed neurochemical signaling by neurons of the ventral tegmental area
نویسندگان
چکیده
منابع مشابه
The Response of Ventral Tegmental Area Dopaminergic Neurons to Bupropion: Excitation or Inhibition?
Introduction: Antidepressants can modulate brain monoamines by acting on pre-synaptic and postsynaptic receptors. Autoreceptors can reduce the monoamines effect on the somatodendritic or pre-synaptic regions despite its postsynaptic counter effects. The direct effect of some antidepressants is related to its temporal and spatial bioavailability in the vicinity of these receptors (still a matter...
متن کاملElectrophysiological characterization of GABAergic neurons in the ventral tegmental area.
GABAergic neurons in the ventral tegmental area (VTA) play a primary role in local inhibition of mesocorticolimbic dopamine (DA) neurons but are not physiologically or anatomically well characterized. We used in vivo extracellular and intracellular recordings in the rat VTA to identify a homogeneous population of neurons that were distinguished from DA neurons by their rapid-firing, nonbursting...
متن کاملNicotine Control of Dopamine Signaling in the Ventral Tegmental Area
Midbrain dopaminergic (DA) neurons signal motivational properties of natural reinforces and addictive drugs. Nicotine, like other drugs of abuse, boosts DA output from the ventral tegmental area (VTA). This increase results from direct stimulation of nicotinic acetylcholine receptors (nAChRs) expressed in the VTA. However, how the DA signal is constructed in the VTA and how nicotine changes thi...
متن کاملQuantitative unit classification of ventral tegmental area neurons in vivo.
Neurons in the ventral tegmental area (VTA) synthesize several major neurotransmitters, including dopamine (DA), GABA, and glutamate. To classify VTA single-unit neural activity from freely moving rats, we used hierarchical agglomerative clustering and probability distributions as quantitative methods. After many parameters were examined, a firing rate of 10 Hz emerged as a transition frequency...
متن کاملCharacterization of M-current in ventral tegmental area dopamine neurons.
M-current (I(M)) is a voltage-gated potassium current (KCNQ type) that affects neuronal excitability and is modulated by some drugs of abuse. Ventral tegmental area (VTA) dopamine (DA) neurons are important for the reinforcing effects of drugs of abuse. Therefore we studied I(M) in acutely dissociated rat DA VTA neurons with nystatin-perforated patch recording. The standard deactivation protoco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chemical Neuroanatomy
سال: 2016
ISSN: 0891-0618
DOI: 10.1016/j.jchemneu.2015.12.016